![]() Cell counting was also conducted in vitro to determine whether albumin contributes to neuronal death. In the present study, electroencephalogram recordings were conducted to record seizure onset, Nissl and Evans blue staining were used to detect neuronal damage and albumin extravasation, respectively, and double immunofluorescence was used to explore neuronal absorption of albumin. Previous studies have predominantly focused on the effect of albumin absorption by astrocytes however, the present study investigated the effects of neuronal uptake of albumin in vitro and in kainic acid‑induced Sprague‑Dawley rat models of temporal lobe epilepsy. However, the effect of albumin extravasation on the development of epilepsy is yet to be fully elucidated. It is well established that brain blood barrier dysfunction following the onset of seizures may lead to serum albumin extravasation into the brain.
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